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Preclinical studies have shown that NR supplementation in aged murine models significantly enhances mitochondrial function, leading to attenuation of cardiac hypertrophy and cognitive impairment

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D-serine, an isomer of serine (L-serine), can restrict CD8 + T cells responses through the inhibition of the transcription factor T-box expressed in T cells (T-bet), restraining IFNy production

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ASCO 2010 Meeting, 2009